[Cryosurgical ablation of bone tissue with a newly developed miniature
cryoprobe--adaptation of the method for use in bones in vitro and
[Article in German]
Popken F, Bertram C, Land M, Konig DP, Bilgic M, Jeschkeit S, Hackenbroch
MH, Fischer JH.
Klinik und Poliklinik fur Orthopadie der Universitat Koln, Koln.
AIM: Up to now, modern miniature cryoprobes have been used successfully
for local destruction of soft tissue tumors without damaging adjacent
healthy tissue. In this study, the methodology of cryoablation was
applied to bone and the freezing effect as well as the cooling capacity
of the probe was examined in vivo and in vitro. METHODS: Freezing
was performed by cooling one or two probes, with a diameter of 3.2
mm to -180 degrees C with liquid nitrogen. The cooling capacity
of the probes was determined under thermic control by an in vitro
measurement on human bone, followed by an in vivo measurement on
femoral and tibia bones of a sheep. RESULTS: The in vitro freezings
achieved a sufficient tissue cooling using one or two cryoprobes.
The simultaneous use of 2 probes resulted in a synergistic effect
between the probes. According to the body heat, the registered temperature
curves, during the in vivo freezings, showed a more flat trend.
Nevertheless, temperatures below -50 degrees C were achieved at
a distance of 1 cm from the probe due to the synergistic effect.
Local or systematical intraoperative complications have not been
observed. CONCLUSION: An adequate tissue cooling of bone matrix
can be achieved within in vivo freezings through the use of one
or more miniature cryoprobes so that the use of this probe could
possibly become an alternative or supplement to the surgical resection
of pathologic bone processes.
PMID: 11253524 [PubMed - indexed for MEDLINE]