Bronchoscopic cryotherapy: preliminary experience.
Noppen M, Meysman M, Van Herreweghe R, Lamote
J, D'Haese J, Vincken W.
Interventional Endoscopy Clinic, Respiratory Division, Academic
Hospital AZ-VUB, Laarbeeklaan 101, 1090 Brussels, Belgium. firstname.lastname@example.org
Our preliminary experience with the bronchoscopic application of
cryotherapy using rapid decompression of liquid nitrous oxide as
cooling agent is reported. Seventeen applications through rigid
bronchoscopy in twelve patients were performed. A single cryotherapy
session was successful in the debulking of obstructive malignant
lesions of the central airways in five patients (four non-small
cell carcinoma, one renal cell cancer metastasis), and in the treatment
of a capillary haemangioma (one patient). Two sessions were successful
in the treatment of a metastatic melanoma (one patient) and benign
granulation tissue (one patient). Cryotherapy was also successful
in the treatment of early bronchial cancer (carcinoma in situ) in
four patients, requiring repetitive sessions in two. There were
no complications or side-effects. These preliminary findings confirm
the safety and efficacy of bronchoscopic cryotherapy in a variety
of airway lesions.
PMID: 11383315 [PubMed - indexed for MEDLINE]