[Percutaneous cryosurgery for liver tumors]
[Article in Japanese]
Nakazaki H, Watanabe M, Hasebe Y, Takita W, Ooshiro
M, Seo A, Kurihara A, Kobayashi K, Teramoto T, Hirano K.
First Dept. of Surgery, Toho University School of
A new cryoprobe developed in our department makes
it possible to perform percutaneous cryoablation for small liver
tumors. This cryoprobe is placed into each lesion using an ultrasonic
guidance technique. In this study there were 10 patients with hepatocellular
carcinoma and 5 patients with liver metastases from colorectal carcinoma.
In 6 cases the tumor size was below 2 cm, in 6 cases between 2 and
3 cm, and in 3 cases over 3 cm. Using a cryoprobe of 3 mm in diameter,
each lesion was frozen using liquid nitrogen for 15 or 20 minutes
then thawed for 10 minutes, and repeated. The ice ball was found
to enlarge to 3 cm in 20 minutes and 5 cm in 60 minutes experimentally.
Six cases were CR, 5 PR, 2 NC and 2 PD. After cryoablation, liver
function did not change and there were no complications. However,
as the size of the ice ball was small (about 3 cm), this method
was insufficiently effective in some cases. Percutaneous cryoablation
using this probe should be performed for tumors smaller than 3 cm.
PMID: 11707989 [PubMed - indexed for MEDLINE]