Cryoablation and liver resection for noncolorectal
Goering JD, Mahvi DM, Niederhuber JE, Chicks D, Rikkers LF.
University of Wisconsin-Madison, Department of Surgery
Division of General Surgery, H4/710 Clinical Science Center, 600
Highland Avenue, Madison, WI 53792, USA.
BACKGROUND: Liver resection for noncolorectal liver metastases
has merit for selected primary tumor types. The role of cryosurgical
tumor ablation within this cohort of patients has not been evaluated.
This is a single institutional review of treatment outcomes using
cryosurgical ablation and conventional resection techniques for
noncolorectal liver metastases. METHODS: The medical records of
42 patients undergoing 48 hepatic tumor ablative procedures from
February 1991 through May 2001 at a single institution were retrospectively
reviewed. Overall survival and local hepatic tumor recurrence-free
survival were analyzed for different surgical procedures and primary
tumor types. RESULTS: Overall survival rates at 1, 3, and 5 years
are 82%, 55%, and 39%, respectively (median survival, 45 months).
Local hepatic tumor recurrence-free survival rates for resection
only (n = 25) and cryosurgery with or without resection (n = 23),
at 3 years are 24% and 19%, respectively. The survival rates at
5 years are 40% and 37%, for resection only and cryosurgery with
or without resection, respectively. CONCLUSION: Cryosurgical hepatic
tumor ablation for metastatic noncolorectal primary tumors results
in survival and local hepatic tumor recurrence rates similar to
resection alone. The combination of cryosurgery and resection extends
the cohort of patients with surgically treatable disease.
PMID: 11975925 [PubMed - indexed for MEDLINE]